"1. Use of Pemetrexed disodium in the manufacture of a medicament for
use in combination therapy for inhibiting tumor growth in mammals
wherein said medicament is to be administered in combination with vitamin B12 or a pharmaceutical derivative thereof, said pharmaceutical derivative of vitamin B12 being hydroxocobalamin, cyano-1-0-

5 vergl. oben Ziff. 2.2.

Seite 8
O2015_004

chlorocobalamin, aquocobalaminperchlorate, aquo--0-chlorocobalamin
perchlorate, azidocobalamin, chlorocobalamin or cobalamin.